QUANTITATION OF TOTAL METASTATIC TUMOR VOLUME IN THE RAT-LIVER - CORRELATION OF MR AND HISTOLOGIC MEASUREMENTS

被引：13

作者：

MAHMOOD, U ^{[1
]}

DEVITT, ML ^{[1
]}

KOCHERIL, PG ^{[1
]}

SUTANTOWARD, E ^{[1
]}

BALLON, D ^{[1
]}

SIGURDSON, ER ^{[1
]}

KOUTCHER, JA ^{[1
]}

机构：

[1] MEM SLOAN KETTERING CANC CTR,DEPT MED PHYS,1275 YORK AVE,NEW YORK,NY 10021

来源：

JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING | 1992年 / 2卷 / 03期

关键词：

COMPARATIVE STUDIES; LIVER; MR; LIVER NEOPLASMS; SECONDARY; VOLUME MEASUREMENT;

D O I：

10.1002/jmri.1880020314

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Assessing tumor response to chemotherapy in the liver has always been difficult. Most investigators estimate tumor volume as either a product of the two Perpendicular diameters of a tumor nodule, or, in animal studies, simply count surface tumor nodules. The authors evaluated magnetic resonance (MR) imaging as a technique for determining absolute tumor volume in the liver in an animal model. Specifically, histologic volumetric and MR imaging measurements of tumor and liver volumes were quantitatively compared over a wide range of tumor burdens in a rat model of hepatic metastasis of a colorectal carcinoma. Twenty-three rats were imaged, with two different section thicknesses used in each animal. Both section thicknesses showed highly significant correlations between MR and histologic measurements for both tumor and liver volumes (P < .001). MR imaging may be useful for noninvasively quantifying tumor burden and temporal response of metastatic disease in the liver to novel antineoplastic regimens.

引用

页码：335 / 340

页数：6

共 13 条

[1]

Boring CC, Squires TS, Tong. Cancer statistics. 1991, CA, 41, pp. 19-36, (1991)

[2]

Sugarbaker PH, Kemeny N, Treatment of metastatic cancer to liver, pp. 2275-2298, (1989)

[3]

Kemeny N, Cohen A, Bertino JR, Sigurdson ER, Botet J, Oderman P, Continuous intrahepatic infusion of floxuridine and leucovorin through an implantable pump for the treatment of hepatic metastases from colorectal carcinoma, Cancer, 65, pp. 2446-2450, (1990)

[4]

Dunnington DJ, Buscarino C, Gennaro D, Greig R, Poste G, Characterization of an animal model of metastatic colon carcinoma, Int J Cancer, 39, pp. 248-254, (1987)

[5]

Panis Y, Nordlinger B, Delelo R, Et al., Experimental colorectal liver metastases, J Hepatol, 11, pp. 53-57, (1990)

[6]

Thomas SR, Busse LJ, Schenck JF, Gradient coil technology, pp. 111-141, (1986)

[7]

Tanner JE, Pulsed field gradients for NMR spin‐echo diffusion measurements, Rev Sci Instrum, 36, pp. 1086-1087, (1965)

[8]

Hayes CE, Edelstein WA, Schenck JF, Radio frequency coils, NMR in medicine: the instrumentation and clinical applications, pp. 142-165, (1986)

[9]

Shtern F, Garrido L, Compton C, Swiniarski JK, Lauffer RB, Brady TJ, MR imaging of blood‐borne liver metastases in mice: contrast enhancement with Fe‐EHPG, Radiology, 178, pp. 83-89, (1991)

[10]

Clement O, Muhler A, Vexler V, Berthezene Y, Brasch RC, Gd‐EOB‐DTPA. a new liver‐specific MR contrast agent: relaxivity, kinetics and enhancement patterns in normal rats (abstr), Book of abstracts: Society of Magnetic Resonance in Medicine 1991, (1991)

← 1 2 →