ASYMMETRIC-SYNTHESIS OF ALPHA-AMINO-ACIDS VIA CATIONIC AZA-COPE REARRANGEMENTS

被引：25

作者：

AGAMI, C

COUTY, F

LIN, J

MIKAELOFF, A

POURSOULIS, M

机构：

[1] Laboratoire de Chimie Organique (URA CNRS 408), Boîte 181, Université P.et M. Curie, 4 place Jussieu

来源：

TETRAHEDRON | 1993年 / 49卷 / 33期

关键词：

D O I：

10.1016/S0040-4020(01)87201-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ene-iminium intermediates resulting from reaction between glyoxal and beta-amino alcohols rearrange by an aza-Cope process. Three different tandem reactions are thus carried out; their first component is this cationic rearrangement, the second step being either an iminium hydrolysis, a nucleophile-induced ene-iminium cyclization or a Mannich reaction. The last two sequences lead to homochiral proline derivatives.

引用

页码：7239 / 7250

页数：12

共 38 条

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AGAMI C, 1992, SYNLETT, P847

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