CERAMIDE - AN ENDOGENOUS REGULATOR OF APOPTOSIS AND GROWTH SUPPRESSION

被引：178

作者：

PUSHKAREVA, M ^{[1
]}

OBEID, LM ^{[1
]}

HANNUN, YA ^{[1
]}

机构：

[1] DUKE UNIV,MED CTR,DEPT MED,DURHAM,NC 27710

来源：

IMMUNOLOGY TODAY | 1995年 / 16卷 / 06期

关键词：

D O I：

10.1016/0167-5699(95)80184-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The action of several cytokines is mediated via activation of the sphingomyelin cycle of signal transduction. Ceramide, the product of this pathway, is emerging as an intracellular messenger that mediates effects on terminal differentiation, apoptosis and cell-cycle arrest. Here, Marina Pushkareva, Lina Obeid and Yusuf Hannun discuss the regulation and mechanism of-action of this stress-activated pathway.

引用

页码：294 / 297

页数：4

共 33 条

[1] BALLOU LR, 1992, J BIOL CHEM, V267, P20044
[2] BETTS JC, 1994, J BIOL CHEM, V269, P8455
[3] APOPTOTIC SIGNALING THROUGH CD95 (FAS/APO-1) ACTIVATES AN ACIDIC SPHINGOMYELINASE
CIFONE, MG
DEMARIA, R
RONCAIOLI, P
RIPPO, MR
AZUMA, M
LANIER, LL
SANTONI, A
TESTI, R
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (04) : 1547 - 1552
[4] DBAIBO GS, 1993, J BIOL CHEM, V268, P17762
[5] RETINOBLASTOMA GENE-PRODUCT AS A DOWNSTREAM TARGET FOR A CERAMIDE-DEPENDENT PATHWAY OF GROWTH ARREST
DBAIBO, GS
PUSHKAREVA, MY
JAYADEV, S
SCHWARZ, JK
HOROWITZ, JM
OBEID, LM
HANNUN, YA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (05) : 1347 - 1351
[6] ACTIVATION OF THE SPHINGOMYELIN CYCLE THROUGH THE LOW-AFFINITY NEUROTROPHIN RECEPTOR
DOBROWSKY, RT
WERNER, MH
CASTELLINO, AM
CHAO, MV
HANNUN, YA
[J]. SCIENCE, 1994, 265 (5178) : 1596 - 1599
[7] GOMEZMUNOZ A, 1994, J BIOL CHEM, V269, P8937
[8] HAIMOVITZFRIEDM.A, 1994, J EXP MED, V180, P525
[9] GLYCOSPHINGOLIPIDS IN CELLULAR INTERACTION, DIFFERENTIATION, AND ONCOGENESIS
HAKOMORI, SI
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1981, 50 : 733 - 764
[10] HANNUN YA, 1994, J BIOL CHEM, V269, P3125

← 1 2 3 4 →