RAT SALIVARY-GLAND BLOOD-FLOW AND BLOOD-TO-TISSUE PARTITION-COEFFICIENTS FOLLOWING X-IRRADIATION

被引：20

作者：

HIRAMATSU, Y

NAGLER, RM

FOX, PC

BAUM, BJ

机构：

[1] Clinical Investigations and Patient Care Branch, National Institute of Dental Research, National Institutes of Health, Bethesda

来源：

ARCHIVES OF ORAL BIOLOGY | 1994年 / 39卷 / 01期

关键词：

RADIATION; SALIVARY GLANDS; IODOANTIPYRINE; BLOOD FLOW; BLOOD-TO-TISSUE PARTITION COEFFICIENT;

D O I：

10.1016/0003-9969(94)90038-8

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Effects of a single high dose of X-irradiation (15 Gy) to the head and neck region in adult male rats were examined. Three days after radiation, rats were infused with [C-14]-iodoantipyrine (IAP) via the femoral vein. Animals were killed at designated times thereafter and the three major salivary glands removed. The uptake of IAP by these tissues was analysed using a pharmacokinetic model. Radiation had relatively modest effects on all measured variables when compared with results from the non-irradiated control and pair-fed groups.

引用

页码：77 / 80

页数：4

共 20 条

[1] RAT PAROTID CELL-FUNCTION INVITRO FOLLOWING X-IRRADIATION INVIVO [J].

BODNER, L ;

KUYATT, BL ;

HAND, AR ;

BAUM, BJ .

RADIATION RESEARCH, 1984, 97 (02) :386-395

[2] PERMEABILITY OF CAPILLARIES IN VARIOUS ORGANS AS DETERMINED BY USE OF INDICATOR DIFFUSION METHOD [J].

CRONE, C .

ACTA PHYSIOLOGICA SCANDINAVICA, 1963, 58 (04) :292-&

[3]

DREIZEN S, 1976, CANCER, V38, P273, DOI 10.1002/1097-0142(197607)38:1<273::AID-CNCR2820380141>3.0.CO

[4]

2-8

[5] EARLY MEMBRANE INJURY IN LETHALLY IRRADIATED SALIVARY-GLAND CELLS [J].

ELMOFTY, SK ;

KAHN, AJ .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1981, 39 (01) :55-62

[6]

FAJARDO LF, 1989, FRONT RADIAT THER ON, V23, P96

[7]

Giebisch G., 1979, MEMBRANE TRANSPORT B, VIV B, P563, DOI 10.1007/978-3-642-81256-9_3

[8] KINETIC-ANALYSIS OF RAT PAROTID-GLAND MUSCARINIC RECEPTORS INVIVO - COMPARISON WITH BRAIN AND HEART [J].

HIRAMATSU, Y ;

KAWAI, R ;

REBA, RC ;

SIMON, TR ;

BAUM, BJ ;

BLASBERG, RG .

AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 264 (03) :G541-G552

[9]

KASHIMA HK, 1965, AMER J ROENTGENOL RA, V94, P271

[10] EFFECT OF IONIZING-RADIATION ON SYMPATHETIC-NERVE FUNCTION IN RAT PAROTID-GLANDS [J].

KOHN, WG ;

GROSSMAN, E ;

FOX, PC ;

ARMANDO, I ;

GOLDSTEIN, DS ;

BAUM, BJ .

JOURNAL OF ORAL PATHOLOGY & MEDICINE, 1992, 21 (03) :134-137

← 1 2 →