ARACHIDONIC-ACID BLOCKS GAP-JUNCTIONS BETWEEN RETINAL HORIZONTAL CELLS

被引：26

作者：

MIYACHI, E ^{[1
]}

KATO, C ^{[1
]}

NAKAKI, T ^{[1
]}

机构：

[1] KEIO UNIV,SCH MED,DEPT PHARMACOL,SHINJUKU KU,TOKYO 160,JAPAN

来源：

NEUROREPORT | 1994年 / 5卷 / 04期

关键词：

RETINA; HORIZONTAL CELL; GAP JUNCTION; ELECTRICAL COUPLING; ELECTRICAL SYNAPSE; ARACHIDONIC ACID; LIPOXYGENASE METABOLITE; GUANYLATE CYCLASE; CGMP;

D O I：

10.1097/00001756-199401120-00029

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

HORIZONTAL cells in turtle retinae are electrically coupled via gap junctions, and the input resistances of the cells are too low to be measured. However, intracellular injection of arachidonic acid into horizontal cells caused great increases in the input resistances of the cells, and the cells could be easily polarized by intracellular current injection. The injection of arachidonic acid also caused decrease in light responses of horizontal cells to surround illumination, and blocked dye-couplings with Lucifer Yellow CH. On the other hand, injection of a lipoxygenase inhibitor or a guanylate cyclase inhibitor into horizontal cells suppressed the decoupling effect of arachidonic acid. These findings suggest that lipoxygenase metabolites of arachidonic acid block gap junctions by activating guanylate cyclase.

引用

页码：485 / 488

页数：4

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