CHIRAL BIO-RESOLUTION OF RACEMIC INDENE OXIDE BY FUNGAL EPOXIDE HYDROLASES

被引：42

作者：

ZHANG, JY ^{[1
]}

REDDY, J ^{[1
]}

ROBERGE, C ^{[1
]}

SENANAYAKE, C ^{[1
]}

GREASHAM, R ^{[1
]}

CHARTRAIN, M ^{[1
]}

机构：

[1] MERCK & CO INC,MERCK SHARP & DOHME RES LABS,RAHWAY,NJ 07065

来源：

JOURNAL OF FERMENTATION AND BIOENGINEERING | 1995年 / 80卷 / 03期

关键词：

BIOCONVERSION; BIOPROCESS; INDANOXIDE;

D O I：

10.1016/0922-338X(95)90823-I

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Eighty fungal strains were evaluated for their production of an epoxide hydrolase capable of catalyzing the kinetic resolution of racemic indene oxide into 1(S),2(R) indene oxide. This screen identified Diplodia gossipina ATCC 16391 as the best catalyst. Process development studies of this bio-resolution demonstrated that the optical purity of the 1(S),2(R) indene oxide produced was dependent upon pH and substrate concentration. A shake-flask-scale bio-resolution process supported the production of preparative quantities of optically pure (ee = 100%) 1(S),2(R) indene oxide.

引用

页码：244 / 246

页数：3

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