PREPARATION OF CHOLESTEROL-25-3H

被引：4

作者：

JOLY, RA

SAUER, HH

BONNER, J

机构：

[1] Division of Biology, California Institute of Technology, Pasadena, California

来源：

JOURNAL OF LABELLED COMPOUNDS | 1969年 / 5卷 / 01期

关键词：

D O I：

10.1002/jlcr.2590050112

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The synthesis of cholesterol‐25‐3H (9) described here starts with the readily available 3β‐hydroxy‐δ5‐cholenic acid (1). The acetate of this acid was converted to the next higher homolog by the Arndt‐Eistert method. Grignard reaction with methyl iodide gave 25‐hydroxycholesterol (6), which was then brominated. Tritium was finally introduced by treating the 25‐bromocholesterol (8) with LiAl3H4. Copyright © 1969 John Wiley & Sons, Ltd.

引用

页码：80 / &

共 16 条

[1] AN IMPROVED METHOD OF PREPARATION OF SIDE-CHAIN LABELED CHOLESTEROL [J].