ENZYMIC PROPERTIES OF A NEW MECHANISM-BASED SUBSTRATE FOR DIHYDROFOLATE-REDUCTASE

被引:17
作者
THIBAULT, V
KOEN, MJ
GREADY, JE
机构
[1] UNIV SYDNEY,DEPT BIOCHEM,SYDNEY,NSW 2006,AUSTRALIA
[2] UNIV SYDNEY,DEPT ORGAN CHEM,SYDNEY,NSW 2006,AUSTRALIA
关键词
D O I
10.1021/bi00440a048
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:6042 / 6049
页数:8
相关论文
共 56 条
[1]  
APPLEMAN JR, 1988, J BIOL CHEM, V263, P9187
[2]   DIHYDROPTERIDINE REDUCTASE (DHPR), ITS COFACTORS, AND ITS MODE OF ACTION [J].
ARMAREGO, WLF ;
RANDLES, D ;
WARING, P .
MEDICINAL RESEARCH REVIEWS, 1984, 4 (03) :267-321
[3]   REDUCED 2-METHYL-4-OXO, 2-METHYLAMINO-4-OXO, 2-METHYLTHIO-4-OXO AND 2-AMINO-4-THIOXO 6,7-DIMETHYLPTERIDINES, AND 6,8-DIMETHYLPTERIN AS SUBSTRATES FOR DIHYDROPTERIDINE REDUCTASE [J].
ARMAREGO, WLF ;
OHNISHI, A ;
TAGUCHI, H .
AUSTRALIAN JOURNAL OF CHEMISTRY, 1986, 39 (01) :31-41
[4]   6,6-DIMETHYLPTERINS - STABLE QUINOID DIHYDROPTERIN SUBSTRATE FOR DIHYDROPTERIDINE REDUCTASE AND TETRAHYDROPTERIN COFACTOR FOR PHENYLALANINE-HYDROXYLASE [J].
BAILEY, SW ;
AYLING, JE .
BIOCHEMISTRY, 1983, 22 (08) :1790-1798
[5]   THE BINDING OF TRIMETHOPRIM TO BACTERIAL DIHYDROFOLATE-REDUCTASE [J].
BAKER, DJ ;
BEDDELL, CR ;
CHAMPNESS, JN ;
GOODFORD, PJ ;
NORRINGTON, FEA ;
SMITH, DR ;
STAMMERS, DK .
FEBS LETTERS, 1981, 126 (01) :49-52
[6]   INSIGHTS INTO ENZYME FUNCTION FROM STUDIES ON MUTANTS OF DIHYDROFOLATE-REDUCTASE [J].
BENKOVIC, SJ ;
FIERKE, CA ;
NAYLOR, AM .
SCIENCE, 1988, 239 (4844) :1105-1110
[7]  
Blakley R. L., 1984, FOLATES PTERINES, P191
[8]  
Blakley R. L., 1969, FRONT BIOL
[9]   CRYSTALLINE DIHYDROPTEROYLGLUTAMIC ACID [J].
BLAKLEY, RL .
NATURE, 1960, 188 (4746) :231-232
[10]  
BOLIN JT, 1982, J BIOL CHEM, V257, P13650