VACCINATION WITH A LIVE RETROVIRUS - THE NATURE OF THE PROTECTIVE IMMUNE-RESPONSE

被引：36

作者：

RUPRECHT, RM

MULLANEY, S

BERNARD, LD

SOSA, MAG

HOM, RC

FINBERG, RW

机构：

[1] HARVARD UNIV, SCH MED, DEPT PATHOL, BOSTON, MA 02115 USA

[2] HARVARD UNIV, SCH MED, DEPT MED, BOSTON, MA 02115 USA

[3] HARVARD UNIV, SCH MED, DANA FARBER CANC INST, INFECT DIS LAB, BOSTON, MA 02115 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1990年 / 87卷 / 14期

关键词：

3'-azido-3'-deoxythymidine and interferon α combination therapy; Cellular immunity; Postexposure prophylaxis; Rauscher murine leukemia virus;

D O I：

10.1073/pnas.87.14.5558

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We tested 3'-azido-3'-deoxythymidine (zidovudine) combined with interferon α as chemoprophylaxis after exposing mice to Rauscher murine leukemia virus. Therapy started 4 hr after inoculation and administered for 20 days prevented viremia and disease in all 234 mice tested. When the animals were rechallenged with live virus after cessation of therapy, 96% were resistant. The nature of this protective immune response was analyzed: passive serotherapy of naive mice challenged subsequently with Rauscher murine leukemia virus was only protective at a high dose of immune serum. Immune, but not naive, T cells alone were fully protective against virus challenge. We conclude that vaccination with a live retrovirus that cannot replicate because of pharmacological blockade induces a T-cell response capable of protecting against a lethal retrovirus-induced disease.

引用

页码：5558 / 5562

页数：5

共 28 条

[1] SYNTHESIS OF AVIAN ONCORNAVIRUS DNA IN INFECTED CHICKEN CELLS [J].