LIPOSOME-INCORPORATED CORTICOSTEROIDS .2. THERAPEUTIC ACTIVITY IN EXPERIMENTAL ARTHRITIS

被引：43

作者：

PHILLIPS, NC ^{[1
]}

THOMAS, DPP ^{[1
]}

KNIGHT, CG ^{[1
]}

DINGLE, JT ^{[1
]}

机构：

[1] STRANGEWAYS RES LAB,TISSUE PHYSIOL,CAMBRIDGE CB1 4RN,ENGLAND

来源：

ANNALS OF THE RHEUMATIC DISEASES | 1979年 / 38卷 / 06期

关键词：

D O I：

10.1136/ard.38.6.553

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The anti-inflammatory activity of liposomes containing cortisol palmitate was determined in experimental acute arthritis in the rabbit knee by measuring joint temperature and diameter. The therapeutic activity of the liposome preparation was dose-dependent for both these parameters of inflammation. Liposomal corticosteroid therapy was effective also in decreasing the joint temperature of an acute inflammatory 'flare' superimposed on an underlying chronic arthritis. Phosphatidic acid was necessary for expression of full anti-inflammatory activity of the liposome preparation.

引用

页码：553 / 557

页数：5

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