EFFECTS OF ARABINOSYL-CYTOSINE ON THYMIDINE TRIPHOSPHATE POOLS AND POLYOMA DNA-REPLICATION

被引：35

作者：

HELLGREN, D

NILSSON, S

REICHARD, P

机构：

[1] Medical Nobel Institute, Department of Biochemistry, Karolinska Institute

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 88卷 / 01期

关键词：

D O I：

10.1016/0006-291X(79)91690-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Arabinosyl cytosine at very low concentrations (5-100 nmolar) inhibits the incorporation of [3H]thymidine into polyoma DNA of infected mouse fibroblasts without affecting the labeling of the [3H]dTTP pool. The specific activities of these pools were determined by a new simple method. Inhibition of DNA synthesis affects chain elongation and not initiation of new rounds of replication. © 1979.

引用

页码：16 / 22

页数：7

共 10 条

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