THE SPLEEN IN HIV-INFECTION - MORPHOLOGICAL EVIDENCE OF HIV-ASSOCIATED MACROPHAGE DYSFUNCTION

被引：19

作者：

FALK, S

STUTTE, HJ

机构：

[1] Senckenbergisches Zentrum der Pathologie, Klinikum der J.W. Goethe-Universität, Frankfurt am Main

来源：

RESEARCH IN VIROLOGY | 1990年 / 141卷 / 02期

关键词：

AIDS; Macrophage; Spleen; Lymphocyte; HIV; S100; protein; Opportunistic infections;

D O I：

10.1016/0923-2516(90)90018-E

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

One-hundred spleens from HIV-infected patients which were studied by conventional morphological and immunohistochemical methods exhibited alterations in lymphatic tissue as well as in the mononuclear phagocyte system (MPS): these were probably related directly to HIV infection of lymphocytes and MPS cells. There was ample evidence of impairment of macrophage activation, accompanied by decreased expression of functional markers and an enhanced reactivity with antibodies against S100 protein. This impairment of macrophage function is related to the particular morphology and aggressive clinical behaviour of some opportunistic infections in AIDS. © 1990.

引用

页码：161 / 169

页数：9

共 18 条

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[2]

BENDER BS, 1988, REV INFECT DIS, V10, P1142

[3]

BIBERFELD P, 1985, CANCER RES, V45, P4665

[4] THE SPLEEN IN ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) [J].