THE ROLE OF LIPID-PEROXIDATION PRODUCTS IN CUMENE HYDROPEROXIDE-INDUCED CA2+ EFFLUX FROM MITOCHONDRIA

被引：9

作者：

GOGVADZE, VG

ZHUKOVA, AA

机构：

[1] Institute of Theoretical and Experimental Biophysics, USSR Academy of Sciences, Pushchino

来源：

FEBS LETTERS | 1991年 / 287卷 / 1-2期

关键词：

MITOCHONDRIA; LIPID PEROXIDATION; CALCIUM; CUMENE HYDROPEROXIDE;

D O I：

10.1016/0014-5793(91)80034-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cumene hydroperoxide-induced calcium release from mitochondria has been studied. Activation of lipid peroxidation by increasing concentrations of cumene hydroperoxide does not enhance calcium efflux induced by low (up to 50-mu-M) concentration of cumene hydroperoxide. It is concluded that cumene hydroperoxide-induced calcium release depends mainly on processes coupled to hydroperoxide reduction by an endogenous enzyme system.

引用

页码：139 / 141

页数：3

共 13 条

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