PASSIVE PROTECTION AGAINST INFECTIOUS BURSAL DISEASE VIRUS BY VIRAL VP2 EXPRESSED IN YEAST

被引：53

作者：

MACREADIE, IG

VAUGHAN, PR

CHAPMAN, AJ

MCKERN, NM

JAGADISH, MN

HEINE, HG

WARD, CW

FAHEY, KJ

AZAD, AA

机构：

[1] CSIRO,DIV BIOMOLEC ENGN,343 ROYAL PARADE,PARKVILLE,VIC 3052,AUSTRALIA

[2] CSIRO,DIV ANIM HLTH,PARKVILLE,VIC 3052,AUSTRALIA

来源：

VACCINE | 1990年 / 8卷 / 06期

关键词：

IBDV VP2; passive protection; recombinant subunit vaccine; Yeast expression;

D O I：

10.1016/0264-410X(90)90006-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Infectious bursal disease virus (IBDV), a pathogen of major economic importance to the world's poultry industries, causes a severe immunodepressive disease in young chickens. Maternal antibodies are able to protect the progeny passively from IBDV infection. The gene encoding the IBDV host-protective antigen (VP2) has been cloned and expressed in yeast resulting in the production of an antigen that very closely resembles native VP2. When injected into specific pathogen free chickens a single dose of microgram quantities of the yeast derived antigen induces high titres of virus neutralizing antibodies that are capable of passively protecting young chickens from infection with IBDV. © 1990.

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页码：549 / 552

页数：4

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