MINIMAL REV-RESPONSE ELEMENT FOR TYPE-1 HUMAN-IMMUNODEFICIENCY-VIRUS

被引：112

作者：

HUANG, XJ

HOPE, TJ

BOND, BL

MCDONALD, D

GRAHL, K

PARSLOW, TG

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT PATHOL,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,DEPT MICROBIOL & IMMUNOL,SAN FRANCISCO,CA 94143

来源：

JOURNAL OF VIROLOGY | 1991年 / 65卷 / 04期

关键词：

D O I：

10.1128/JVI.65.4.2131-2134.1991

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Rev protein regulates nuclear export of viral mRNAs that contain a 240-base RNA sequence termed the Rev-response element (RRE). We demonstrate that an 88-base truncated RRE encompassing a known Rev binding site can mediate Rev responsiveness in vivo. Two tandem copies of this mutant function as efficiently as the full-length RRE.

引用

收藏

页码：2131 / 2134

页数：4

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