EPIDEMIOLOGIC STUDIES OF ESCHERICHIA-COLI DIARRHEAL INFECTIONS IN A LOW SOCIOECONOMIC LEVEL PERIURBAN COMMUNITY IN SANTIAGO, CHILE

被引:136
作者
LEVINE, MM
FERRECCIO, C
PRADO, V
CAYAZZO, M
ABREGO, P
MARTINEZ, J
MAGGI, L
BALDINI, MM
MARTIN, W
MANEVAL, D
KAY, B
GUERS, L
LIOR, H
WASSERMAN, SS
NATARO, JP
机构
[1] UNIV MARYLAND, SCH MED, DIV INFECT DIS & TROP PEDIAT, BALTIMORE, MD 21201 USA
[2] MINIST SALUD, PROGRAM CONTROL TYPHOID FEVER & ENTER DIS, SANTIAGO, CHILE
[3] CANADIAN CTR DIS CONTROL, ENTER REFERENCE LAB, OTTAWA, ON, CANADA
关键词
CHILD; DIARRHEA; INFANTILE; GASTROENTERITIS; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; SOCIOECONOMIC FACTORS;
D O I
10.1093/oxfordjournals.aje.a116788
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The incidence of diarrhea due to sir: categories of diarrheogenic Escherichia coli was determined in two pediatric cohorts in a low socioeconomic level community in Santiago, Chile, with access to chlorinated water. An age cross-sectional cohort of 340 children aged birth to 47 months was assembled. A newborn cohort was assembled by enrolling 10-12 newborns monthly for 12 months. Episodes of diarrhea were detected by twice weekly household visits. E. coli from stool cultures of cases and matched controls were hybridized with DNA probes specific for enterotoxigenic, enteroinvasive, enteropathogenic, enterohemorrhagic, enteroaggregative, and diffuse adherence E. coli. Overall, the incidence of diarrhea was low (2.1 episodes/infant/year). Nevertheless, a putative E. coli enteropathogen was found in a large proportion of diarrheal episodes, particularly during the summer. In both cohorts, enterotoxigenic E. coli were important pathogens. Enteropathogenic E. coli were incriminated during the first year of life in the newborn cohort, where they were found significantly more often in cases (p = 0.021) than in controls; beyond this age, isolation rates were similar. In contrast, the relative risk of isolation of diffuse adherence E. coli increased with age in the age cross-sectional cohort, where, overall, the difference in rate of isolation between cases and controls was significant (p = 0.0024). Enteroinvasive and enterohemorrhagic E. coli were isolated infrequently. Enteroaggregative E. coli were encountered equally in cases and controls. Facile transmission of E. coli enteropathogens is occurring in this community despite the availability of potable water.
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收藏
页码:849 / 869
页数:21
相关论文
共 87 条
  • [1] ACUTE DIARRHEAL DISEASE IN CHILDREN UNDER 7 YEARS OF AGE IN A PERI-URBAN SLUM OF SANTIAGO, CHILE
    ARAYA, M
    FIGUEROA, G
    ESPINOZA, J
    MONTESINOS, N
    SPENCER, E
    BRUNSER, O
    [J]. JOURNAL OF HYGIENE, 1985, 95 (02): : 457 - 467
  • [2] ENTEROAGGREGATIVE ESCHERICHIA-COLI STRAINS SECRETE A HEAT-LABILE TOXIN ANTIGENICALLY RELATED TO ESCHERICHIA-COLI HEMOLYSIN
    BALDWIN, TJ
    KNUTTON, S
    SELLERS, L
    HERNANDEZ, HAM
    AITKEN, A
    WILLIAMS, PH
    [J]. INFECTION AND IMMUNITY, 1992, 60 (05) : 2092 - 2095
  • [3] ENTEROPATHOGENS ASSOCIATED WITH ACUTE AND PERSISTENT DIARRHEA IN BANGLADESHI CHILDREN LESS-THAN-5 YEARS OF AGE
    BAQUI, AH
    SACK, RB
    BLACK, RE
    HAIDER, K
    HOSSAIN, A
    ALIM, ARMA
    YUNUS, M
    CHOWDHURY, HR
    SIDDIQUE, AK
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1992, 166 (04) : 792 - 796
  • [4] A SENSITIVE AND SPECIFIC DNA PROBE TO IDENTIFY ENTEROAGGREGATIVE ESCHERICHIA-COLI, A RECENTLY DISCOVERED DIARRHEAL PATHOGEN
    BAUDRY, B
    SAVARINO, SJ
    VIAL, P
    KAPER, JB
    LEVINE, MM
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1990, 161 (06) : 1249 - 1251
  • [5] BHAN MK, 1989, B WORLD HEALTH ORGAN, V67, P281
  • [6] ENTEROAGGREGATIVE ESCHERICHIA-COLI ASSOCIATED WITH PERSISTENT DIARRHEA IN A COHORT OF RURAL CHILDREN IN INDIA
    BHAN, MK
    RAJ, P
    LEVINE, MM
    KAPER, JB
    BHANDARI, N
    SRIVASTAVA, R
    KUMAR, R
    SAZAWAL, S
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1989, 159 (06) : 1061 - 1064
  • [7] MOLECULAR CHARACTERIZATION OF A FIMBRIAL ADHESIN, F1845, MEDIATING DIFFUSE ADHERENCE OF DIARRHEA-ASSOCIATED ESCHERICHIA-COLI TO HEP-2 CELLS
    BILGE, SS
    CLAUSEN, CR
    LAU, W
    MOSELEY, SL
    [J]. JOURNAL OF BACTERIOLOGY, 1989, 171 (08) : 4281 - 4289
  • [8] COLONIZATION FACTORS OF ENTEROTOXIGENIC ESCHERICHIA-COLI ISOLATED FROM CHILDREN WITH DIARRHEA IN ARGENTINA
    BINSZTEIN, N
    JOUVE, MJ
    VIBOUD, GI
    MORAL, LL
    RIVAS, M
    ORSKOV, I
    AHREN, C
    SVENNERHOLM, AM
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1991, 29 (09) : 1893 - 1898
  • [9] LONGITUDINAL-STUDIES OF INFECTIOUS-DISEASES AND PHYSICAL GROWTH OF CHILDREN IN RURAL BANGLADESH .2. INCIDENCE OF DIARRHEA AND ASSOCIATION WITH KNOWN PATHOGENS
    BLACK, RE
    BROWN, KH
    BECKER, S
    ALIM, ARMA
    HUQ, I
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 1982, 115 (03) : 315 - 324
  • [10] INCIDENCE AND ETIOLOGY OF INFANTILE DIARRHEA AND MAJOR ROUTES OF TRANSMISSION IN HUASCAR, PERU
    BLACK, RE
    DEROMANA, GL
    BROWN, KH
    BRAVO, N
    BAZALAR, OG
    KANASHIRO, HC
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 1989, 129 (04) : 785 - 799