LITHIUM INTERMEDIATES DURING THE ALPHA-LITHIATION AND SUBSEQUENT ALPHA-SUBSTITUTION OF HETEROCYCLIC AMINES IN THE PRESENCE OF CO2

被引：36

作者：

BALL, SC

CRAGGHINE, I

DAVIDSON, MG

DAVIES, RP

EDWARDS, AJ

LOPEZSOLERA, I

RAITHBY, PR

SNAITH, R

机构：

[1] University Chemical Laboratory, Cambridge, CB21EW, Lensfield Road

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1995年 / 34卷 / 08期

关键词：

ELECTROPHILIC SUBSTITUTION; HETEROCYCLES; LITHIATION; LITHIUM COMPOUNDS;

D O I：

10.1002/anie.199509211

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two interdependent steps appear to be involved in the CO2‐mediated electrophilic substitution of cyclic amines in the α position. The key finding is that the lithium carbamate 1 is not lithiated with tBuLi to any extent, but reacts only after addition of electrophiles like Me3SiCl to give the desired α‐substitution product 2. (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany

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页码：921 / 923

页数：3

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