CHOLINE CHLORIDE IN ANIMAL-MODELS OF TARDIVE-DYSKINESIA

被引：15

作者：

DAVIS, KL ^{[1
]}

HOLLISTER, LE ^{[1
]}

VENTO, AL ^{[1
]}

SIMONTON, S ^{[1
]}

机构：

[1] STANFORD UNIV, SCH MED, PALO ALTO, CA 94304 USA

来源：

LIFE SCIENCES | 1978年 / 22卷 / 19期

关键词：

D O I：

10.1016/0024-3205(78)90621-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Rats treated chronically with haloperidol show evidence of supersensitive dopamine receptors by increased stereotypy when challenged with apomorphine. When such animals are treated acutely with choline chloride at the time of challenge, no changes in stereotypy were observed. Chronic treatment, either during or after induction of supersensitivity, mitigated stereotypy after challenge. This model of dopaminergic supersensitivity is pertinent to the development of tardive dyskinesia in man after treatment with neuroleptic drugs. Our results with choline chloride in the animal model are consistent with their therapeutic action in tardive dyskinesia. © 1978.

引用

页码：1699 / 1707

页数：9

共 21 条

[1] ANTI-SCHIZOPHRENIC DRUGS - CHRONIC TREATMENT ELEVATES DOPAMINE RECEPTOR-BINDING IN BRAIN [J].