DIFFERENT BLAST KINETICS IN ACUTE MYELOBLASTIC AND LYMPHOBLASTIC LEUKAEMIA - A HYPOTHESIS OF DIFFERENT STEM CELL ORIGIN

被引：19

作者：

GAVOSTO, F

PILERI, A

PONZONE, A

MASERA, P

TAROCCO, RP

GABUTTI, V

机构：

[1] Haematology Laboratory, General Medical Clinic, University of Turin, Turin

来源：

ACTA HAEMATOLOGICA | 1969年 / 41卷 / 04期

关键词：

D O I：

10.1159/000208853

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In acute myeloblastic leukaemia (AML) and acute lymphoblastic leukaemia (ALL) the kinetics of cell populations in function of blast diameters was analysed after single and repeated in vivo labelling with3H-thymidine. In ALL, as opposed to AML, the behaviour of the large blasts was more similar to that of a self-maintaining system. Furthermore both marrow and peripheral blood blast kinetics suggested an extramedullary origin in some of the ALL eases. These data are discussed in regard to a possible difference in stem cell origin in ALL and AML. © 1969 S. Karger AG, Basel.

引用

页码：215 / &

共 20 条

[1] STUDIES OF CELLULAR PROLIFERATION IN HUMAN LEUKEMIA .I. ESTIMATION OF GROWTH RATES OF LEUKEMIC AND NORMAL HEMATOPOIETIC CELLS IN 2 ADULTS WITH ACUTE LEUKEMIA GIVEN SINGLE INJECTIONS OF TRITIATED THYMIDINE [J].