STRUCTURE AND DEVELOPMENTAL EXPRESSION OF THE D-ALPHA-2 GENE ENCODING A NOVEL NICOTINIC ACETYLCHOLINE-RECEPTOR PROTEIN OF DROSOPHILA-MELANOGASTER

被引：33

作者：

JONAS, P ^{[1
]}

BAUMANN, A ^{[1
]}

MERZ, B ^{[1
]}

GUNDELFINGER, ED ^{[1
]}

机构：

[1] UNIV HAMBURG,KRANKENHAUS EPPENDORF,ZENTRUM MOLEK NEUROBIOL,ZMNH,MARTINISTR 52,W-2000 HAMBURG 20,GERMANY

来源：

FEBS LETTERS | 1990年 / 269卷 / 01期

关键词：

Development; Drosophila melanogaster; Evolution; Gene structure; Nervous system; Nicotinic acetylcholine receptor;

D O I：

10.1016/0014-5793(90)81170-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nicotinic acetylcholine receptors (nAChRs) represent a heterogeneous group of excitatory neurotransmitter receptors in the insect brain. We have characterized the Dα2 gene of Drosophila melanogaster, a new member of the nAChR gene family. The protein coding region is interrupted by six introns. The positions of three of these introns are shared with all other nAChR genes. The deduced Dα2 protein shows the structural features of ligand-binding nAChR α-subunits. Cytogenetically, the Dα2 gene maps at position 96A of the 3rd chromosome, close to the ALS gene which also encodes an α-like nAChR subunit. Dα2 transcripts are predominantly expressed in late embryos and in fly heads. © 1990.

引用

页码：264 / 268

页数：5

共 32 条

[1]

ASHBURNER M, 1989, DROSOPHILA LABORATOR

[2]

BAUMANN A, 1990, IN PRESS NUCL ACIDS

[3] CONSERVATION OF NEURAL NICOTINIC ACETYLCHOLINE-RECEPTORS FROM DROSOPHILA TO VERTEBRATE CENTRAL NERVOUS SYSTEMS [J].