THE EFFECT OF 2-AMINO-4-PHOSPHONOBUTYRIC ACID ON THE OSCILLATORY POTENTIALS OF THE ELECTRORETINOGRAM

被引:18
作者
GUITE, P
LACHAPELLE, P
机构
[1] MCGILL UNIV,MONTREAL CHILDRENS HOSP,DEPT OPHTHALMOL,2300 RUE TUPPER,MONTREAL H3H 1P3,QUEBEC,CANADA
[2] MCGILL UNIV,DEPT NEUROL & NEUROSURG,MONTREAL H3A 2T5,QUEBEC,CANADA
关键词
2-amino-4-phosphonobutyric acid; electroretinogram; oscillatory potentials;
D O I
10.1007/BF00146548
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Previous reports have shown that an intravitreal injection of 2-amino-4-phosphonobutyric acid, a glutamate analogue that selectively blocks the photoreceptors' input to the on-bipolar cells, produces a rapid decrease in the amplitude of the electroretinographic b-wave. To our knowledge, the effect of this glutamate analogue has not been examined on the oscillatory potentials. We therefore conducted such a study. A needle electrode was inserted into the anterior chamber of the eyes of seven anesthetized and paralyzed rabbits to record simultaneously the electroretinogram and the oscillatory potentials. These responses were evoked by flashes of white light delivered in mesopic conditions. As expected, an injection of 2-amino-4-phosphonobutyric acid, produced a rapid decrease in the amplitude of the b-wave, while the a-wave was relatively spared. The amplitude of the oscillatory potentials also decreased rapidly. At maximal effect, the electroretinogram essentially consisted of a normal a-wave followed by small oscillations and no evidence of a b-wave. The 100-1000 Hz recording confirmed that the oscillations seen on the postinjection electroretinograms were remnants of the original oscillatory potentials. © 1990 Kluwer Academic Publishers.
引用
收藏
页码:125 / 133
页数:9
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