ANTI-DIABETOGENIC EFFECT OF FUSIDIC ACID IN DIABETES PRONE BB RATS

被引：25

作者：

BUSCHARD, K

PEDERSEN, C

HANSEN, SV

HAGEMAN, I

AAEN, K

BENDTZEN, K

机构：

[1] Bartholin Instituttet, Kommunehospitalet, Copenhagen

[2] Laboratory of Medical Immunology, Rigshospitalet, Copenhagen

来源：

AUTOIMMUNITY | 1992年 / 14卷 / 02期

关键词：

FUSIDIC ACID; INSULIN DEPENDENT DIABETES-MELLITUS; BB RATS; INSULITIS;

D O I：

10.3109/08916939209083127

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Fusidic acid and its sodium salt (fusidin) are anti-staphylococcal drugs. In vitro studies have shown that they prevent the lymphocyte co-stimulatory activities of the cytokines IL-1 and IL-6 in a manner similar to that of cyclosporin A, and prevent the inhibitory effect of IL-1 on glucose-induced insulin production. As IL-1 and IL-6 are thought to play a role in the pathogenesis of Type 1 diabetes, the aim of this study was to investigate whether fusidin could influence the disease incidence of the spontaneously diabetic BB rat model. Accordingly, a group of 50 BB rats receiving fusidin dissolved in their drinking water were compared to a control group of 55 rats over a period of 200 days. The incidence of diabetes was found to be 52% in the experimental group and 71% in the control group (P<0.05). The degree of insulitis and the number of islets at histological examination were similar among the non-diabetic animals whereas the diabetic fusidin-treated animals showed a higher degree of islet preservation than the diabetic control rats. The results are highly indicative of an anti-diabetogenic effect of fusidin.

引用

页码：101 / 104

页数：4

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