NATURAL-HISTORY OF HLA EXPRESSION DURING TUMOR-DEVELOPMENT

被引：447

作者：

GARRIDO, F

CABRERA, T

CONCHA, A

GLEW, S

RUIZCABELLO, F

STERN, PL

机构：

[1] HOSP VIRGEN NIEVES, DEPT ANAT PATOL, GRANADA, SPAIN

[2] CHRISTIE HOSP & HOLT RADIUM INST, NHS TRUST, PATERSON INST CANC RES, DEPT IMMUNOL, MANCHESTER M20 9BX, LANCS, ENGLAND

来源：

IMMUNOLOGY TODAY | 1993年 / 14卷 / 10期

关键词：

D O I：

10.1016/0167-5699(93)90264-L

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HLA expression is frequently altered in tumours compared to the tissue from which they originate. Given the central role of MHC products in the restriction of T-cell recognition, regulation of tumour HLA expression might be a strategy for the evasion of immune surveillance by the malignant cells. Federico Garrido, Peter Stern and colleagues present data from a variety of tumour types, suggesting that HLA class I alterations may occur at a particular step between the development of an in situ lesion and an invasive carcinoma.

引用

页码：491 / 499

页数：9

共 72 条

[1] PEPTIDE-INDUCED STABILIZATION AND INTRACELLULAR-LOCALIZATION OF EMPTY HLA CLASS-I COMPLEXES [J].