RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM ANALYSIS OF MYCOBACTERIUM-TUBERCULOSIS ISOLATED FROM PATIENTS WITH PULMONARY TUBERCULOSIS IN NORTHERN TANZANIA

被引：27

作者：

GILLESPIE, SH

KENNEDY, N

NGOWI, FI

FOMUKONG, NG

ALMAAMARY, S

DALE, JW

机构：

[1] KILIMANJIRO CHRISTIAN MED CTR,MOSHI,TANZANIA

[2] UNIV SURREY,SCH BIOL SCI,GUILDFORD GU2 5XH,SURREY,ENGLAND

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1995年 / 89卷 / 03期

关键词：

TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS; RESTRICTION FRAGMENT LENGTH POLYMORPHISM ANALYSIS; STRAIN RELATIONSHIPS; TANZANIA;

D O I：

10.1016/0035-9203(95)90571-5

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Isolates of Mycobacterium tuberculosis from 88 patients with pulmonary tuberculosis in northern Tanzania were subjected to IS6110 restriction fragment length polymorphism (RFLP) analysis. Of 88 isolates, 73 fell into 11 groups of which 9 contained 2-5 isolates. Of 2 large homology groups one, group H (20 isolates), was isolated only from patients resident in the Kilimanjiro region, whereas 79% of isolates from other groups came from this region. A significant association(P=0.023) was found between another group, M (24 isolates) and isolation from patients of the Masai tribe. The data from this pilot study support the idea that IS6110 RFLP analysis provides information which may be of value in the control of tuberculosis in Africa.

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收藏

页码：335 / 338

页数：4

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