RADIATION CHEMISTRY OF BIOCHEMICAL DISULFIDES .2. LIPOIC ACID

被引:10
作者
OWEN, TC
WILBRAHA.AC
机构
[1] Department of Chemistry, University of South Florida, Tampa
关键词
D O I
10.1021/ja01040a045
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
α-Lipoic acid (6-thioctic acid) (I) is destroyed in high yield upon exposure to X-rays in aerated or de-aerated aqueous solution. Small amounts, only, of thiol and of oxidation products (sulfonic and sulfinic acid, etc.) and hydrogen peroxide are produced. The major product appears to be a cyclic dimer. A mechanism is presented which accommodates all of the experimental observations. Kinetic treatment of the mechanism affords it support and requires a linear increase in radiation-chemical yield with concentration such that G0(-lipoate) = 2(GOH + GH) + K[lipoate] at lipoate concentrations above 5-10 mM. The radiobiological significance of the work is briefly discussed. © 1969, American Chemical Society. All rights reserved.
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页码:3365 / &
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