TOXICITY OF HYDROXYAPATITE INVITRO - THE EFFECT OF PARTICLE-SIZE

被引：66

作者：

EVANS, EJ

机构：

[1] Department of Anatomy, University of Wales College, Cardiff

来源：

BIOMATERIALS | 1991年 / 12卷 / 06期

基金：

英国惠康基金;

关键词：

HYDROXYAPATITE; BIOCOMPATIBILITY; PARTICLE SIZE; FIBROBLASTS;

D O I：

10.1016/0142-9612(91)90054-E

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Finely ground powders of synthetic hydroxyapatite applied to fibroblasts in vitro reduced the total growth rate and mitotic rate of the cells and increased the number of pycnotic cells. The effect was dose related and only occurred with small particles. The small particles appear to either adhere to the cells or are phagocytosed by them and the toxic effect may be physical rather than chemical.

引用

页码：574 / 576

页数：3

共 7 条

[1]

AOKI H, 1986, ADV BIOMATER, V6, P1

[2]

DELANGE GL, 1984, ADV BIOMATER, V5, P451

[3] THE INVITRO TOXICITY OF COBALT-CHROME-MOLYBDENUM ALLOY AND ITS CONSTITUENT METALS [J].