RESULTS AND CONCLUSIONS OF THE NATIONAL TOXICOLOGY PROGRAMS RODENT CARCINOGENICITY STUDIES WITH SODIUM-FLUORIDE

被引：35

作者：

BUCHER, JR ^{[1
]}

HEJTMANCIK, MR ^{[1
]}

TOFT, JD ^{[1
]}

PERSING, RL ^{[1
]}

EUSTIS, SL ^{[1
]}

HASEMAN, JK ^{[1
]}

机构：

[1] BATTELLE MEM INST,COLUMBUS,OH 43201

来源：

INTERNATIONAL JOURNAL OF CANCER | 1991年 / 48卷 / 05期

关键词：

D O I：

10.1002/ijc.2910480517

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The US National Toxicology Program (NTP) has conducted toxicity and carcinogenicity studies with sodium fluoride administered in the drinking water to F344/N rats and B6C3F1 mice. The drinking water concentrations used in the 2-year studies were 0, 25, 100, or 175 ppm sodium fluoride (equivalent to 0, 11, 45 or 79 ppm fluoride). Survival and weight gains of rats and mice were not affected by fluoride treatment. Animals receiving sodium fluoride developed effects typical of dental fluorosis, and female rats given 175 ppm had increased osteosclerosis. There were no increases in neoplasms in female rats or in male or female mice that were attributed to sodium fluoride administration. There was equivocal evidence of carcinogenic activity of sodium fluoride in male rats based on the occurrence of a small number of osteosarcomas in treated animals.

引用

页码：733 / 737

页数：5

共 31 条

[1] SODIUM FLUORIDE-INDUCED CHROMOSOME-ABERRATIONS IN DIFFERENT STAGES OF THE CELL-CYCLE - A PROPOSED MECHANISM [J].