DIRECT EVIDENCE FOR MEDIATION OF AN ANTICONFLICT EFFECT OF BACLOFEN BY GABA-B RECEPTORS

被引：24

作者：

SHEPHARD, RA

WEDLOCK, P

WILSON, NE

机构：

[1] Behavioural Analysis and Behavioural Biology Research Centre, University of Ulster at Jordanstown Newtownabbey

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1992年 / 41卷 / 03期

关键词：

BACLOFEN; DELTA-AMINO-N-VALERIC ACID; GABA; CONFLICT BEHAVIOR;

D O I：

10.1016/0091-3057(92)90387-U

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The present article reports an experiment on the effects of baclofen (0, 0.5, 1.0, and 2.0 mg/kg) on punished drinking in rats and the modification of these by delta-amino-n-valeric acid (DANVA) (0 and 10.0 mg/kg). Baclofen significantly enhanced punished drinking and this increase was abolished by DANVA, which had no intrinsic anxiogenic activity. It is concluded that GABAb receptors probably mediate this effect of baclofen and that such receptors may be a potential site of anxiolytic drug action.

引用

页码：651 / 653

页数：3

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