APPARATUS FOR THE CONTROL OF BREATHING PATTERNS DURING AEROSOL INHALATION

被引：19

作者：

PHIPPS, PR

GONDA, I

ANDERSON, SD

机构：

[1] GENENTECH INC,460 POINT SAN BRUNO BLVD,SAN FRANCISCO,CA 94080

[2] UNIV SYDNEY,DEPT PHARM,SYDNEY,NSW 2006,AUSTRALIA

来源：

JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG | 1992年 / 5卷 / 03期

关键词：

BREATHING PATTERN; INHALATION; AEROSOL INHALATION; CONTROL OF BREATHING PATTERN;

D O I：

10.1089/jam.1992.5.155

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

A computerized breathing circuit for monitoring, recording and controlling aerosol inhalation patterns is described. A target pattern, using sine functions derived from previous recording of breathing, is displayed on the computer screen. The reproducibility of tidal breathing patterns of nine normal volunteers was compared using: (i) no target, (ii) a metronome and tidal volume (V(t)) target and (iii) the full control provided by this system. Each 'subject breathed for 2 minutes using each method on separate days. The breath-by-breath variability was found to be similar for all methods. The day-to-day variation was greatest for the 'no control' method with the exception of inspiratory pause (P(i)). The inspiratory flow rate (F(i)) and P(i) had a greater variation using the metronome than the full control. The V(t) and breathing frequency were equally well controlled using these two methods. This system provides better control with an easy to follow target display of the subject's own, or pre-set inhalation pattern.

引用

页码：155 / 170

页数：16

共 34 条

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