FACILE CHEMOENZYMATIC PREPARATION OF ENANTIOMERICALLY PURE 2-METHYLGLYCEROL DERIVATIVES AS VERSATILE TRIFUNCTIONAL C4-SYNTHONS

被引：34

作者：

WIRZ, B ^{[1
]}

BARNER, R ^{[1
]}

HUBSCHER, J ^{[1
]}

机构：

[1] HOFFMANN LA ROCHE LTD,PHARMACEUT RES NEW TECHNOL,DEPT PHYS,CH-4002 BASEL,SWITZERLAND

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1993年 / 58卷 / 15期

关键词：

D O I：

10.1021/jo00067a034

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Both enantiomers of a series of synthetically valuable 2-methylglycerol derivatives have been prepared with >99% ee using a chemoenzymatic reaction sequence. The introduction of chirality was achieved by enantioselective esterification of 1,2-O-protected 2-methylglycerol 3 or enantioselective hydrolysis of its butyryl ester 4. The enzymatic reaction proceeded with unusually high selectivity and velocity for a primary alcohol (ester) substrate.

引用

页码：3980 / 3984

页数：5

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