MURINE CYTOMEGALOVIRUS - ASSOCIATED PNEUMONITIS IN THE LUNGS FREE OF THE VIRUS

被引：37

作者：

TANAKA, K

KOGA, Y

LU, YY

ZHANG, XY

WANG, Y

KIMURA, G

NOMOTO, K

机构：

[1] KYUSHU UNIV,MED INST BIOREGULAT,DEPT VIROL,FUKUOKA 812,JAPAN

[2] KYUSHU UNIV,MED INST BIOREGULAT,DEPT IMMUNOL,FUKUOKA 812,JAPAN

[3] TOKAI UNIV,SCH MED,DEPT INFECT DIS,ISEHARA,KANAGAWA 25911,JAPAN

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1994年 / 94卷 / 03期

关键词：

CYTOMEGALOVIRUS; PNEUMONITIS; IMMUNOSUPPRESSION; CYTOKINE RELEASE SYNDROME; PERSISTENT VIRAL INFECTION;

D O I：

10.1172/JCI117415

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

At 4 wk after intraperitoneal inoculation of murine cytomegalovirus (MCMV) in adult BALB/c mice, MCMV remained detectable only in the salivary glands. When T cells of these mice were activated by a single injection of anti-CD3 epsilon monoclonal antibody, mice died of interstitial pneumonitis at 24-48 h after injection, accompanied by elevation of serum levels of TNF-alpha and IFN-gamma. However, MCMV remained undetectable in the lungs during the period. Simultaneous injection of cyclosporin A reduced such effects of anti-CD3. In conclusion, although the presence of MCMV in the host may be required, MCMV-associated pneumonitis is not mediated by virus in the lung but probably by the cytokines released from T cells, of which responsiveness to stimulation via CD3 molecule has been presumably modified by MCMV infection.

引用

页码：1019 / 1025

页数：7

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