ANTIINFLAMMATORY MECHANISM OF CORDIACHROMENE-A ACTION

被引：20

作者：

BENSLIMANE, AF

POUCHUS, YF

VERBIST, JF

PETIT, JY

BRION, JD

WELIN, L

机构：

[1] UNIV NANTES,FAC PHARM,SUBSTANCES MARINES ACT BIOL RES GRP,F-44035 NANTES,FRANCE

[2] UNIV NANTES,FAC PHARM,PHARMACOL LAB,F-44035 NANTES,FRANCE

[3] UNIV NANTES,FAC PHARM,THERAPEUT CHEM LAB,F-44035 NANTES,FRANCE

来源：

JOURNAL OF CLINICAL PHARMACOLOGY | 1995年 / 35卷 / 03期

关键词：

D O I：

10.1002/j.1552-4604.1995.tb04063.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The mechanism of antiinflammatory action of cordiachromene A, isolated from the chloromethylenic extract of the ascidian Aplidium antillense or chemically synthesized, was studied using different in vivo and in vitro inhibition tests on enzymes of the cyclooxygenase cascade. Cordiachromene A inhibits prostacyclin synthesis and arachidonic acid metabolism but not phospholipase A(2) and peroxidase. The mechanism of action, already known to be stereospecific, operates by cyclooxygenase inhibition.

引用

页码：298 / 301

页数：4

共 14 条

[1] ALTERED FUNCTION OF SYNOVIAL-FLUID GRANULOCYTES IN PATIENTS WITH ACUTE INFLAMMATORY ARTHRITIS - EVIDENCE FOR ACTIVATION OF NEUTROPHILS AND ITS MEDIATION BY A FACTOR PRESENT IN SYNOVIAL-FLUID [J].