ALUMINUM NEUROTOXICITY - AN EXPERIMENTAL APPROACH TO THE INDUCTION OF NEUROFILAMENTOUS INCLUSIONS

被引：18

作者：

STRONG, MJ

机构：

[1] Department of Clinical Neurological Sciences, University of Western Ontario, University Hospital, London, Ont. N6A 5A5, Rm 10LY1

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1994年 / 124卷

关键词：

ALUMINUM; NEUROFILAMENT PHOSPHORYLATION; AMYOTROPHIC LATERAL SCLEROSIS; NEUROTOXICITY;

D O I：

10.1016/0022-510X(94)90172-4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Acute or chronic aluminum neurotoxicity experiments in the rabbit suggest that aluminum can induce phosphorylation of neurofilamentous proteins. This may result in abnormal resistance to degradation or transport of neurofilament protein and so to the accumulation of neurofilaments in abnormal cells. The possible importance of this process in ALS is considered in relation to the neurofilamentous abnormalities characteristic of intraneuronal inclusions in ALS and in other neurodegenerative disorders.

引用

页码：20 / 26

页数：7

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