MEAN DOSE TO LYMPHOCYTES DURING RADIOTHERAPY TREATMENTS

被引:4
作者
BRANDAN, ME
PEREZPASTENES, MA
OSTROSKYWEGMAN, P
GONSEBATT, ME
DIAZPERCHES, R
机构
[1] UNIV NACL AUTONOMA MEXICO, INST INVEST BIOMED, MEXICO CITY 04510, DF, MEXICO
[2] HOSP GEN MEXICO SA, SERV ONCOL, MEXICO CITY, DF, MEXICO
来源
HEALTH PHYSICS | 1994年 / 67卷 / 04期
关键词
CO-60; RADIATION; MEDICAL; DOSE; BLOOD;
D O I
10.1097/00004032-199410000-00002
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Using a probabilistic model with parameters from four radiotherapy protocols used in Mexican hospitals for the treatment of cervical cancer, we have calculated the distribution of dose to cells in peripheral blood of patients. Values of the mean dose to the lymphocytes during and after a Co-60 treatment are compared to estimates from an in vivo chromosome aberration study performed on five patients. Calculations indicate that the mean dose to the circulating blood is about 2% of the tumor dose, while the mean dose to recirculating lymphocytes may reach up to 7% of the tumor dose. Differences up to a factor of two in the dose to the blood are predicted for different protocols delivering equal tumor doses. The data suggest mean doses higher than the predictions of the model.
引用
收藏
页码:326 / 329
页数:4
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