INHIBITORS OF PROTEIN-TYROSINE KINASE PP60(V-SRC) STEROL SULFATES FROM THE BRITTLE STAR OPHIARACHNA-INCRASSATA

被引：40

作者：

FU, X

SCHMITZ, FJ

LEE, RH

PAPKOFF, JS

SLATE, DL

机构：

[1] UNIV OKLAHOMA,DEPT CHEM & BIOCHEM,NORMAN,OK 73019

[2] SYNTEX INC,DISCOVERY RES,INST BIOCHEM & CELL BIOL,PALO ALTO,CA 94304

来源：

JOURNAL OF NATURAL PRODUCTS-LLOYDIA | 1994年 / 57卷 / 11期

关键词：

D O I：

10.1021/np50113a023

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioactivity-guided fractionation of the extracts of the green brittle star Ophiarachna incrassata using a protein tyrosine kinase pp 60(v-src) inhibition assay led to the isolation of a new sterol sulfate [2] together with four known ones (1,3-5). All five compounds were found to inhibit protein tyrosine kinase pp 60(v-src).

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页码：1591 / 1594

页数：4

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