ANTICONVULSANT EFFECTS OF PROPRANOLOL AND BETA-ADRENERGIC-BLOCKADE

被引：36

作者：

JAEGER, V

ESPLIN, B

CAPEK, R

机构：

[1] Department of Pharmacology and Therapeutics, McGill University, Montreal, H3G 1Y6, Quebec

来源：

EXPERIENTIA | 1979年 / 35卷 / 01期

关键词：

D O I：

10.1007/BF01917889

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The anticonvulsant activity of racemic and (+)-propranolol was studied in rats. Neither drug changed the current to produce a minimal seizure in 50% of animals. Both drugs were effective in the maximal electroshock seizure test, the (+) isomer being more potent than the racemic form. Since the (+) isomer is practically devoid of β-adrenergic blocking activity, the anticonvulsant effects of propranolol do not result from β-adrenergic blockade. © 1979 Birkhäuser Verlag.

引用

页码：80 / 81

页数：2

共 11 条

[1] TRANQUILLIZING EFFECTS OF PROPRANOLOL DEMONSTRATED IN RATS [J].