SYNTHESIS OF PYRROLIDINE-SUBSTITUTED NICOTINE ANALOGS

被引：5

作者：

CASTAGNO.N

MELIKIAN, AP

ROSNATI, V

机构：

[1] Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco Medical Center, San Francisco, California

[2] Instituto Chimica Organica Industriale, University of Milan

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 07期

关键词：

IR spectrophotometry–structure; Nicotine analog; pyrrolidine substituted–synthesis; NMR spectroscopy–structure; UV spectrophotometry–structure;

D O I：

10.1002/jps.2600580715

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

As part of a program to synthesize nicotine homologs and analogs, the potentially versatile condensation of 3‐pyridyl lithium with a 1‐pyrroline‐1‐oxide (cyclic nitrone) has been studied. The product, an N‐hydroxynornicotine derivative, was obtained in moderate yield and could be converted by way of the corresponding myosmine and nornicotine compounds to the desired gemdimethylnicotine homolog. Spectral characteristics of these and certain side products are reported. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：860 / &

共 33 条

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