SENSITIVE HIGH-PRESSURE LIQUID-CHROMATOGRAPHIC DETERMINATION OF PROPRANOLOL IN PLASMA

被引:35
作者
NYGARD, G [1 ]
SHELVER, WH [1 ]
WAHBAKHALIL, SK [1 ]
机构
[1] N DAKOTA STATE UNIV,COLL PHARM,FARGO,ND 58105
关键词
Cardiac depressants—propranolol; high‐pressure liquid chromatographic analysis in plasma; High‐pressure liquid chromatography—analysis; propranolol in plasma; Propranolol—high‐pressure liquid chromatographic analysis in plasma;
D O I
10.1002/jps.2600680336
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A high‐pressure liquid chromatographic method is presented for the determination of propranolol in human plasma. A reversed‐phase cyanopropylsilane column was utilized with a liquid phase consisting of 70% acetonitrile and 30% 0.02 M acetate buffer, pH 7.0. A spectrofluorometric detector with an excitation wavelength of 276 nm and an emission filter with a 340‐nm cutoff provided a detectable peak for 0.8 ng of propranolol/injection with this system. The reproducibility and precision of the method are shown from the analyses of samples containing 10‐150 ng/ml of plasma. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company
引用
收藏
页码:379 / 381
页数:3
相关论文
共 11 条
[1]  
AMBLER PK, 1974, ACTA CLIN CHIM, V54, P373
[2]  
CLEVELAND CR, 1972, CLINICAL PHARMACOLOG, V13, P181
[3]   SENSITIVE GAS-CHROMATOGRAPHIC METHOD FOR DETERMINATION OF PROPRANOLOL IN HUMAN PLASMA [J].
DISALLE, E ;
BAKER, KM ;
BAREGGI, SR ;
WATKINS, WD ;
CHIDSEY, CA ;
FRIGERIO, A ;
MORSELLI, PL .
JOURNAL OF CHROMATOGRAPHY, 1973, 84 (02) :347-353
[4]  
ESLER M, 1977, CLIN PHARMACOL THER, V22, P299
[5]  
KAWASHIMA K, 1976, J PHARMACOL EXP THER, V196, P517
[6]  
KORNHAUSER DM, 1978, CLIN PHARMACOL THER, V23, P165
[7]  
KRAML M, 1978, CLIN CHEM, V24, P169
[8]   IMPROVED FLUORIMETRIC ASSAY OF PLASMA PROPRANOLOL [J].
OFFERHAUS, L ;
VANDERVECHT, JR .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1976, 3 (06) :1061-1062
[9]  
VERVLOET E, 1977, CLIN PHARMACOL THER, V22, P853
[10]   SIMULTANEOUS DETERMINATION OF PROPRANOLOL AND 4-HYDROXYPROPRANOLOL IN PLASMA BY MASS FRAGMENTOGRAPHY [J].
WALLE, T ;
MORRISON, J ;
WALLE, K ;
CONRADI, E .
JOURNAL OF CHROMATOGRAPHY, 1975, 114 (02) :351-359