TOPOSTIN, A NOVEL INHIBITOR OF MAMMALIAN DNA TOPOISOMERASE-I FROM FLEXIBACTER-TOPOSTINUS SP-NOV .1. TAXONOMY, AND FERMENTATION OF PRODUCING STRAIN

被引：19

作者：

SUZUKI, K

YAMAGUCHI, H

MIYAZAKI, S

NAGAI, K

WATANABE, S

SAITO, T

ISHII, K

HANADA, M

SEKINE, T

IKEGAMI, Y

ANDOH, T

机构：

[1] MEIJI COLL PHARM,DEPT HYG CHEM,TANASHI,TOKYO 188,JAPAN

[2] YAMANOUCHI PHARMACEUT CO LTD,CENT RES LABS,BIOSCI RES LABS,TOKYO 174,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 02期

关键词：

D O I：

10.7164/antibiotics.43.154

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We found a new inhibitor of mammalian DNA topoisomerase I, named topostin, from a bacterial culture. The bacteria was identified as Flexibacter topostinus sp. nov., B-572. Morphological and physiological characteristics, and utilization of sugars were examined. Comparison of the strain with known species of the genus Flexibacter was made and indicates that the strain is a new species of the genus Flexibacter. The bacteria produced the inhibitor in parallel with their growth up to 72 hours. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：154 / 157

页数：4

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