INDOMETHACIN AND RENAL-FUNCTION IN PREMATURE-INFANTS WITH PERSISTENT PATENT DUCTUS-ARTERIOSUS

Renal function during indomethacin treatment was studied in 12 premature infants with patent ductusarteriosus. Decreases in urinary flow rate, GFR, and CH by 56, 27, and 66% respectively, occurred during Indo therapy. Urinary excretion rates of ions were also reduced: Na by 70%, Cl by 79%, K by 40%. These changes were accompanied by slight decreases in plasma sodium concentration and osmolality. Except for GFR and urinary Na and osmolality, all these functions retured to pretreatment values one to two weeks after stopping the drug. © 1979 The C. V. Mosby Company.