EFFECTS OF POLYAMINES ON INVITRO PHOSPHORYLATION AND ACETYLATION OF HISTONES OF THE CEREBRAL-CORTEX OF RATS OF VARIOUS AGES

被引：19

作者：

DAS, R ^{[1
]}

KANUNGO, MS ^{[1
]}

机构：

[1] BANARAS HINDU UNIV, DEPT ZOOL, BIOCHEM LAB, VARANASI 221005, UTTAR PRADESH, INDIA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 90卷 / 03期

关键词：

D O I：

10.1016/0006-291X(79)91885-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In vitro phosphorylation and acetylation of histones and their modulation by spermine and spermidine were studied using slices of cerebral cortex of female rats of various ages. Phosphorylation and acetylation of individual histones decrease with increasing age. Spermine and spermidine have stimulatory effects on the modifications of specific histones in immature rats. These effects decrease with increasing age. Such changes in covalent modifications of histones may alter gene expression and contribute to the aging process.

引用

页码：708 / 714

页数：7

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