SYNTHESIS OF CHIRAL ALPHA-ACETYLENIC CYCLIC AMINES FROM ALPHA-AMINO ACIDS - APPLICATIONS TO DIFFERENTIALLY CONSTRAINED OXOTREMORINE ANALOGUES AS MUSCARINIC AGENTS

被引：28

作者：

CHUNG, JYL ^{[1
]}

WASICAK, JT ^{[1
]}

机构：

[1] ABBOTT LABS,DIV NUCL RES,DEPT 47W,PHARMACEUT DISCOVERY,ABBOTT PK,N CHICAGO,IL 60064

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 28期

关键词：

D O I：

10.1016/S0040-4039(00)94471-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Application of the Corey-Fuchs reaction on Boc-prolinal, Boc-4-hydroxyprolinal, Bocpiperidinal and Boc-serinal derivatives to give chiral 2-pyrrolidinyl-, 2-piperidinyl- and 4-oxazolidinyl-acetylene derivatives provided rapid access to a number of differentially constrained oxotremorine analogues as muscarinic agents. © 1990.

引用

页码：3957 / 3960

页数：4

共 9 条

[1] POSITION-5 AT THE OXOTREMORINE SKELETON AS THE STEERING POSITION FOR ACTIVITY AT THE MUSCARINIC RECEPTORS
AMSTUTZ, R
CLOSSE, A
GMELIN, G
[J]. HELVETICA CHIMICA ACTA, 1987, 70 (08) : 2232 - 2244
[2] ALPHA-LITHIOAMINE SYNTHETIC EQUIVALENTS FROM DIPOLE-STABILIZED CARBANIONS - THE TERT-BOC GROUP AS AN ACTIVATOR FOR ALPHA'-LITHIATION OF CARBAMATES
BEAK, P
LEE, WK
[J]. TETRAHEDRON LETTERS, 1989, 30 (10) : 1197 - 1200
[3] COREY EJ, 1972, TETRAHEDRON LETT, V36, P3769
[4] DAVIDSON M, 1988, CURRENT RES ALZHEIME, P333
[5] THE SYNTHESIS AND CONFIGURATIONAL STABILITY OF DIFFERENTIALLY PROTECTED BETA-HYDROXY-ALPHA-AMINO ALDEHYDES
GARNER, P
PARK, JM
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (12) : 2361 - 2364
[6] JURCZAK J, 1989, CHEM REV, V30, P1197
[7] CONFORMATIONALLY RESTRICTED ANALOGS OF THE MUSCARINIC AGENT N-METHYL-N-(1-METHYL-4-PYRROLIDINO-2-BUTYNYL)ACETAMIDE
LUNDKVIST, JRM
RINGDAHL, B
HACKSELL, U
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (04) : 863 - 869
[8] LUNDKVIST JRM, 1990, TETRAHEDRON LETT, V31, P719
[9] TRYBULSKI EJ, 1990, 199TH ACS NAT M BOST

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