DROSOPHILA ALCOHOL-DEHYDROGENASE ACTIVITY INVITRO AND INVIVO - EFFECTS OF ACETONE FEEDING

被引：43

作者：

PAPEL, I ^{[1
]}

HENDERSON, M ^{[1
]}

VANHERREWEGE, J ^{[1
]}

DAVID, J ^{[1
]}

SOFER, W ^{[1
]}

机构：

[1] UNIV LYON 1,ENTOMOL EXPTL & GENET LAB,F-69621 VILLEURBANNE,FRANCE

来源：

BIOCHEMICAL GENETICS | 1979年 / 17卷 / 5-6期

关键词：

acetone; alcohol dehydrogenase; Drosophila; multiple forms;

D O I：

10.1007/BF00498890

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

When adult Drosophila are placed on medium containing 0.5% acetone, their level of alcohol dehydrogenase activity drops rapidly. At the same time, the proportion of activity in the various electrophoretic forms of the enzyme shifts; most of the activity becomes localized in what is ordinarily a minor form of the enzyme. Moreover, the loss of enzyme activity occurs in vivo as well, as shown by sensitivity to ethanol poisoning, insensitivity to pentenol treatment, and inability to utilize ethanol as an energy source. These observations are discussed in light of a model advanced for the origin of the multiple forms of alcohol dehydrogenase in Drosophila. © 1979 Plenum Publishing Corporation.

引用

页码：553 / 563

页数：11

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