INHIBITION OF TGF-ALPHA-INDUCED 2ND MESSENGERS BY ANTI-EGF RECEPTOR ANTIBODY-425

被引：20

作者：

MURTHY, U ^{[1
]}

RIEMAN, DJ ^{[1
]}

RODECK, U ^{[1
]}

机构：

[1] WISTAR INST,PHILADELPHIA,PA 19104

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 172卷 / 02期

关键词：

D O I：

10.1016/0006-291X(90)90696-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Monoclonal antibody 425 binds to a protein epitope of the human EGF receptor and blocks EGF dependent functions such as EGF receptor phosphorylation and mitogenesis (1). We now show that MAb 425 blocks TGFα-induced second messenger signals, namely inositol 1,4,5 triphosphate and Ca2+ in two carcinoma cell lines, A 431 and SW-948. In this study we have further characterized the specificity of this antibody for inhibiting TGFα induced mitogenesis in MRC-5, a EGF-receptor expressing fibroblast cell line. © 1990.

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页码：471 / 476

页数：6

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