ASSIGNMENT OF THE GENE FOR CYCLIC AMP-RESPONSE ELEMENT BINDING PROTEIN-2 (CREB2) TO HUMAN-CHROMOSOME 2Q24.1-Q32

被引：6

作者：

DIEP, A

LI, C

KLISAK, I

MOHANDAS, T

SPARKES, RS

GAYNOR, R

LUSIS, AJ

机构：

[1] UNIV CALIF LOS ANGELES,DEPT MICROBIOL,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,INST MOLEC BIOL,LOS ANGELES,CA 90024

[3] UNIV CALIF LOS ANGELES,LOS ANGELES CTY HARBOR MED CTR,DEPT MED GENET,TORRANCE,CA 90509

来源：

GENOMICS | 1991年 / 11卷 / 04期

关键词：

D O I：

10.1016/0888-7543(91)90047-I

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The regulatory element TGACGTCA is found upstream of a number of viral and cellular genes. This element has been demonstrated to mediate cyclic AMP induction of cellular genes and activation of viral genes. A group of closely related cellular genes known as cyclic AMP-response element binding proteins (CREB) or activating transcription factor (ATF) have been found to bind to this motif and mediate activation by cyclic AMP and the adenovirus E1A protein. One of these genes, CREB1, was previously mapped to human chromosome 2q32.3-q34. Southern blot analysis of genomic DNA from a panel of mouse-human somatic cell hybrids indicated that the CREB2 gene, another member of this family, also resides on human chromosome 2. In situ hybridization further regionalized this gene to 2q24.1-q32. Thus, the genes for CREB1 and CREB2 that have only limited DNA sequence homology map to a similar region of the long arm of chromosome 2, though whether they are part of a gene cluster is unclear. © 1991.

引用

页码：1161 / 1163

页数：3

共 15 条

[1] 2 DISTINCT FORMS OF ACTIVE TRANSCRIPTION FACTOR CREB (CAMP RESPONSE ELEMENT BINDING-PROTEIN) [J].