ROLE OF THE SYSTEMIC CELLULAR IMMUNE-RESPONSE IN THE PATHOGENESIS OF HELICOBACTER-PYLORI-ASSOCIATED DUODENAL-ULCER

被引：10

作者：

KLUGE, A

MIELKE, M

VOLKHEIMER, G

NIEDOBITEK, F

HAHN, H

机构：

[1] GASTROENTEROL FACHPRAXIS, D-10779 BERLIN, GERMANY

[2] AUGUSTE VIKTORIA KRANKENHAUS BERLIN SCHONEBERG, INST PATHOL, D-12157 BERLIN, GERMANY

来源：

ZENTRALBLATT FUR BAKTERIOLOGIE-INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY VIROLOGY PARASITOLOGY AND INFECTIOUS DISEASES | 1993年 / 280卷 / 1-2期

关键词：

D O I：

10.1016/S0934-8840(11)80954-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

20 patients colonized by H. pylori (9 with duodenal ulcer, 11 with antral gastritis) were examined for the presence of a systemic cellular immune response to H. pylori using an in vitro lymphocyte transformation assay. Infiltration of the antral mucosa by myelomonocytic cells was assessed by immunohistology as a parameter of local cellular immune response. A systemic H. pylori-induced cellular reaction could be demonstrated in 11 patients all of whom showed an intense myelomonocytic infiltration of the antral mucosa. In this group 7 of 9 duodenal ulcers occurred. The findings support the hypothesis, that a specific cellular immune response might be involved in the pathogenesis of H. pylori-associated gastritis and duodenal ulcer. A protective role of systemic cellular immunity to H. pylori seems rather unlikely.

引用

收藏

页码：177 / 185

页数：9

相关论文

共 27 条

[1] SINGLE-AGENT PROPHYLAXIS WITH CEFOTETAN IN COLORECTAL SURGERY [J].

ANDREASEN, JJ ;

TRIERMORCH, P ;

NIELSEN, K .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1989, 8 (02) :174-175

[2] REACTIONS IN VIVO AND IN VITRO PRODUCED BY A SOLUBLE SUBSTANCE ASSOCIATED WITH DELAYED-TYPE HYPERSENSITIVITY [J].

BENNETT, B ;

BLOOM, BR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1968, 59 (03) :756-&

[3] HELICOBACTER-PYLORI AND THE PATHOGENESIS OF GASTRODUODENAL INFLAMMATION [J].

BLASER, MJ .

JOURNAL OF INFECTIOUS DISEASES, 1990, 161 (04) :626-633

[4]

BORROMEO M, 1988, GASTRODUODENAL PATHO

[5] MUCOSAL HUMORAL IMMUNE-RESPONSE TO HELICOBACTER-PYLORI IN PATIENTS WITH DUODENITIS [J].

CRABTREE, JE ;

SHALLCROSS, TM ;

WYATT, JI ;

TAYLOR, JD ;

HEATLEY, RV ;

RATHBONE, BJ ;

LOSOWSKY, MS .

DIGESTIVE DISEASES AND SCIENCES, 1991, 36 (09) :1266-1273

[6] MUCOSAL IGA RECOGNITION OF HELICOBACTER-PYLORI 120-KDA PROTEIN, PEPTIC-ULCERATION, AND GASTRIC PATHOLOGY [J].

CRABTREE, JE ;

TAYLOR, JD ;

WYATT, JI ;

HEATLEY, RV ;

SHALLCROSS, TM ;

TOMPKINS, DS ;

RATHBONE, BJ .

LANCET, 1991, 338 (8763) :332-335

[7] ASSOCIATION OF CAMPYLOBACTER-PYLORI WITH INDUCED EXPRESSION OF CLASS-II TRANSPLANTATION ANTIGENS ON GASTRIC EPITHELIAL-CELLS [J].

ENGSTRAND, L ;

SCHEYNIUS, A ;

PAHLSON, C ;

GRIMELIUS, L ;

SCHWAN, A ;

GUSTAVSSON, S .

INFECTION AND IMMUNITY, 1989, 57 (03) :827-832

[8] INOCULATION OF BARRIER-BORN PIGS WITH HELICOBACTER-PYLORI - A USEFUL ANIMAL-MODEL FOR GASTRITIS TYPE-B [J].

ENGSTRAND, L ;

GUSTAVSSON, S ;

JORGENSEN, A ;

SCHWAN, A ;

SCHEYNIUS, A .

INFECTION AND IMMUNITY, 1990, 58 (06) :1763-1768

[9]

FERGUSON A, 1987, IMMUNOPATHOLOGY SMAL, P235

[10] CYTO-TOXIN PRODUCTION BY CAMPYLOBACTER-PYLORI STRAINS ISOLATED FROM PATIENTS WITH PEPTIC-ULCERS AND FROM PATIENTS WITH CHRONIC GASTRITIS ONLY [J].

FIGURA, N ;

GUGLIELMETTI, P ;

ROSSOLINI, A ;

BARBERI, A ;

CUSI, G ;

MUSMANNO, RA ;

RUSSI, M ;

QUARANTA, S .

JOURNAL OF CLINICAL MICROBIOLOGY, 1989, 27 (01) :225-226