APOLIPOPROTEIN-D GENE POLYMORPHISM - A NEW GENETIC-MARKER FOR TYPE-2 DIABETIC SUBJECTS IN NAURU AND SOUTH-INDIA

被引：36

作者：

BAKER, WA ^{[1
]}

HITMAN, GA ^{[1
]}

HAWRAMI, K ^{[1
]}

MCCARTHY, MI ^{[1
]}

RIIKONEN, A ^{[1
]}

TUOMILEHTOWOLF, E ^{[1
]}

NISSINEN, A ^{[1
]}

TUOMILEHTO, J ^{[1
]}

MOHAN, V ^{[1
]}

VISWANATHAN, M ^{[1
]}

SNEHALATHA, C ^{[1
]}

RAMACHANDRAN, A ^{[1
]}

DOWSE, GK ^{[1
]}

ZIMMET, P ^{[1
]}

SERJEANTSON, SW ^{[1
]}

机构：

[1] ROYAL LONDON HOSP,MED UNIT,LONDON E1 1BB,ENGLAND

来源：

DIABETIC MEDICINE | 1994年 / 11卷 / 10期

关键词：

TYPE; 2; DIABETES; GENETICS; APOLIPOPROTEIN D GENE; GLUCOSE TRANSPORTERS; ASSOCIATION;

D O I：

10.1111/j.1464-5491.1994.tb00252.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 2 diabetes is characterized by abnormalities in both glucose and lipoprotein metabolism and genes involved in lipid metabolism are legitimate candidates for involvement in Type 2 diabetes. We have previously reported an association in Nauruans between a Tag 1 polymorphism of the apolipoprotein D gene (ape D) and Type 2 diabetes. In this study these findings were investigated further in the Nauruan population as well as two other ethnic groups. In South Indian subjects, there was a significant difference in genotype distribution of apo D genotypes between diabetic subjects (n = 110) and controls (n = 88; p = 0.004) which was similar to that previously found in the Nauruan subjects. No such association was seen in elderly Finnish subjects (diabetic n = 69; impaired glucose tolerance n = 26 and normal glucose tolerance n = 31). Linkage between the apo D polymorphism,and diabetes in 12 Nauruan families was only excluded under a highly penetrant dominant model and was unlikely under other single gene models. Since the p cell glucose transporter gene (Glut 2) is found in a similar chromosomal location to apo D, South Indian subjects (diabetic n = 95 and controls n = 56) were typed at this locus. No association between diabetes and the Glut 2 Tag I polymorphism was found in the South Indian subjects. Furthermore, there was no evidence of linkage disequilibrium between the apo D and Glut 2 genes. In conclusion, apo D might act as a modifying gene for Type 2 diabetes in some ethnic groups.

引用

页码：947 / 952

页数：6

共 32 条

[1] McCarthy M., Hitman GA., The genetic aspects of non‐insulin‐dependent diabetes mellitus, The Causes of Diabetes, pp. 157-183, (1993)
[2] Serjeantson SW, Zimmet P., Genetics of non‐insulin dependent diabetes mellitus in 1990, Clin Endocrinol Metab, 5, pp. 477-493, (1991)
[3] Froguel PH, Vaxillaire M., Sun F., Velho G., Zouali H., Butel MO, Et al., Close linkage of glucokinase locus on chromosome 7p to early‐onset non‐insulin‐dependent diabetes mellitus, Nature, 356, pp. 162-164, (1990)
[4] Shimada F., Taira M., Suzuki Y., Insulin‐resistant diabetes associated with partial deletion of insulin‐receptor gene, Lancet, 335, pp. 1179-1181, (1990)
[5] Haneda M., Polonsky KS, Bergenstal RM, Jaspan JB, Shoelson SE, Blix PM, Et al., Familial hyperinsulinaemia due to a structurally abnormal insulin: definition of an emerging new clinical syndrome, N Engl J Med, 310, pp. 1288-1294, (1984)
[6] Stoffel M., Froguel PH, Takeda J., Zouali H., Vionnet N., Nishi S., Et al., Human glucokinase gene: isolation, characterisation and identification of two missense mutations linked to early‐onset non‐insulin‐dependent (type 2) diabetes mellitus, Proc Natl Acad Sci, 89, pp. 7698-7702, (1992)
[7] Katagiri H., Asano T., Ishihara H., Inukai K., Anai M., Miyazaki, Et al., Nonsense mutation of glucokinase gene in late‐onset non‐insulin‐dependent diabetes mellitus, Lancet, 340, pp. 1316-1317, (1992)
[8] Jowett, Rees A., Williams AG, Stocks J., Vella MA, Hitman GA, Et al., Insulin and apolipoprotein A‐1/C‐III gene polymorphisms relating to hypertriglyceridaemia and diabetes mellitus, Diabetologia, 27, pp. 180-183, (1984)
[9] Buraczynska M., Hanzlik J., Grzywa M., Apolipoprotein A‐l gene polymorphism and susceptibility of non‐insulin‐dependent diabetes mellitus, Am J Hum Genet, 37, pp. 1129-1137, (1985)
[10] Trembath RC, Thomas DJ, Hendra TJ, Yudkin JS, Galton DJ., Deoxyribonucleic acid polymorphism of the apoprotein Al‐CIII‐AIV gene cluster and coronary heart disease in non‐insulin‐dependent diabetes, Br Med J, 294, pp. 1577-1578, (1987)

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