INTRAMOLECULAR AMIDOALKYLATION OF AROMATICS .2. SYNTHESIS OF CONFORMATIONALLY RESTRICTED BRIDGED PEPTIDES ANALOGS OF PHG-GLY OR GLY-PHG

被引:6
作者
BENISHAI, D
MCMURRAY, AR
机构
[1] Department of Chemistry, Israel Institute of Technology, Haifa
关键词
D O I
10.1016/S0040-4020(01)80154-X
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Derivatives of Phg-alpha-MeO-GlyOH(3) and its isomer alpha-MeO-Gly-Phg(2) were prepared and their inter and intramolecular amidoalkylation reactions were studied. Derivatives of 2 underwent smooth cyclization to give 4-amino-3-isoquinolon-1-carboxylic acid derivatives (4, 8). The isomer 3, which reacted smoothly intermolecularly with toluene to give the open chain peptide 7, reacted sluggishly intramolecularly.
引用
收藏
页码:6399 / 6410
页数:12
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