INTRAMOLECULAR AMIDOALKYLATION OF AROMATICS .2. SYNTHESIS OF CONFORMATIONALLY RESTRICTED BRIDGED PEPTIDES ANALOGS OF PHG-GLY OR GLY-PHG

被引：6

作者：

BENISHAI, D

MCMURRAY, AR

机构：

[1] Department of Chemistry, Israel Institute of Technology, Haifa

来源：

TETRAHEDRON | 1993年 / 49卷 / 29期

关键词：

D O I：

10.1016/S0040-4020(01)80154-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Derivatives of Phg-alpha-MeO-GlyOH(3) and its isomer alpha-MeO-Gly-Phg(2) were prepared and their inter and intramolecular amidoalkylation reactions were studied. Derivatives of 2 underwent smooth cyclization to give 4-amino-3-isoquinolon-1-carboxylic acid derivatives (4, 8). The isomer 3, which reacted smoothly intermolecularly with toluene to give the open chain peptide 7, reacted sluggishly intramolecularly.

引用

页码：6399 / 6410

页数：12

共 9 条

[1]

BELLEAU B, 1967, CAN J CHEM, V35, P651

[2] INTRA VS INTERMOLECULAR AMIDOALKYLATION OF AROMATICS [J].