POTENT ANTITUMOR-ACTIVITY AND LOW TOXICITY OF TUBEIMOSIDE-1 ISOLATED FROM BOLBOSTEMMA-PANICULATUM

被引：72

作者：

YU, LJ

MA, RD

WANG, YQ

NISHINO, H

机构：

[1] SHAANXI PROV HLTH SCH,DEPT PHARM,XIAN,PEOPLES R CHINA

[2] KYOTO PREFECTURAL UNIV MED,DEPT BIOCHEM,KYOTO 602,JAPAN

来源：

PLANTA MEDICA | 1994年 / 60卷 / 03期

关键词：

BOLBOSTEMMA PANICULATUM (MAXIM) FRANQUET; CUCURBITACEAE; TUBEIMOSIDE; 1; ANTITUMOR ACTIVITY; TOXICITY;

D O I：

10.1055/s-2006-959459

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Bolbostemma paniculatum (Maxim.) Franquet (Cucurbitaceae) is a traditional Chinese medicinal plant (1), from which tubeimoside 1 was isolated. The antitumor activity and toxicity of tubeimoside 1 was investigated in vivo and in vitro. The results showed that tubeimoside 1 exerts potent anti-tumor activity with low toxicity. The compound inhibited DNA synthesis and induced phenotypic reverse transformation of tumor cells.

引用

页码：204 / 208

页数：5

共 11 条

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