DISTRIBUTION OF NEUROTROPHIN RECEPTORS IN HUMAN PALATINE TONSILS - AN IMMUNOHISTOCHEMICAL STUDY

被引：33

作者：

HANNESTAD, J

LEVANTI, MB

VEGA, JA

机构：

[1] UNIV OVIEDO,FAC MED,DEPT MORFOL & BIOL CELULAR,E-33006 OVIEDO,SPAIN

[2] UNIV MESSINA,IST ANAT ANIM DOMEST,I-98123 MESSINA,ITALY

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1995年 / 58卷 / 02期

关键词：

NEUROTROPHINS; P75; TRK NEUROTROPHIN RECEPTOR PROTEINS; PALATINE TONSILS; HUMAN; IMMUNOHISTOCHEMISTRY;

D O I：

10.1016/0165-5728(95)00014-S

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Increasing evidence indicates that nerve growth factor (NGF) exerts effects on cells of the immune system, but the possible immunomodulatory effect of other neurotrophins (brain-derived neurotrophic factor, BDNF; neurotrophin-3, NT-3; and NT-4/5) has not been studied. Neurotrophins act on responsive cells by binding a low-affinity pan-neurotrophin receptor (p75), and more specific high-affinity receptors (gp140trkA, gp145trkB and gp145trkC considered as preferred signaling transduction receptors for NGF, BDNF and NT-3, respectively). The expression of neurotrophin receptor proteins may be considered, therefore, as a potential indication of neurotrophin activity. In the present study we investigated the distribution of both types of neurotrophin receptors in the human palatine tonsils using immunohistochemical methods. In the follicular germinal centers both lymphocytes and follicular dendritic cells (FDC) displayed gp75 IR, but not IR for trk neurotrophin receptor proteins. gp140trkA-like IR and gp145trkC-like IR were encountered on paracortical interdigitating cells (PIG), and in the high endothelial venule cells. gp145trkB-like IR was found in a cell subpopulation which probably represented macrophages. Present results suggest that NGF, NT-3 and NT-4/5 may act in PIC and indirectly in lymphocytes, whereas BDNF and NT-4/5 could control macrophages. The role of p75 on lymphocytes and FDC and whether trk neurotrophin receptor proteins present in lymphoid tissues are functional receptors for neurotrophins remains to be elucidated.

引用

页码：131 / 137

页数：7

共 37 条

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